What is motor neuron disease?
MND (including ALS) is a progressive neurodegenerative disorder affecting motor neurons — causing muscle weakness, atrophy and eventually paralysis while sparing sensation.
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Early signs
Hand weakness (difficulty with buttons, grip), foot drop (tripping), slurred speech, muscle cramps and fasciculations, excessive emotional lability.
Evaluation and treatment
Clinical examination, EMG, MRI, blood tests to exclude mimics. Riluzole and edaravone modestly prolong survival. Multidisciplinary care essential. Clinical trials available.