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Less common than B-cell lymphoma, and often more difficult to treat
T-cell lymphomas are a heterogeneous group of nodal, cutaneous and extranodal lymphoid malignancies. Subtype definition requires expert pathology and sometimes molecular studies. Treatment is subtype-specific and may include chemotherapy, targeted agents, radiotherapy, transplant or clinical trials. Relapsed disease remains a major challenge.
Haematology & Haemato-Oncology
Authored and reviewed by Dr. Sachita Baniya (MBBS, FCPS (Clinical Haematology), NMC 20158). Evidence-based, no fabricated outcomes.
T-cell lymphomas are a heterogeneous group of nodal, cutaneous and extranodal lymphoid malignancies. Subtype definition requires expert pathology and sometimes molecular studies. Treatment is subtype-specific and may include chemotherapy, targeted agents, radiotherapy, transplant or clinical trials. Relapsed disease remains a major challenge.
Reviewed by Dr. Sachita Baniya, MBBS, FCPS — Consultant Haemato-Oncologist & Clinical Hematologist (NMC 20158). For evaluation, contact the respective hospital or cancer centre — Kathmandu Cancer Center (KCC) Nepal, Civil Service Hospital Kathmandu, or Advanced Care Hospital.
T-cell lymphoma diagnosis is challenging because reactive T-cell infiltrates can mimic lymphoma. Expert haematopathology review, immunohistochemistry, T-cell receptor clonality and sometimes molecular studies are needed. Staging includes imaging and bone marrow assessment, with subtype-specific evaluation for skin, gut or other extranodal disease.
Treatment depends on subtype and stage. Systemic therapy may include CHOP-like regimens, though some subtypes respond poorly. Brentuximab vedotin is used in CD30-positive disease, and other targeted agents are selected by subtype. Autologous or allogeneic transplant is considered in selected fit patients. Clinical trials are important because standard options are limited in relapsed disease.
Guidelines referenced:
NCCN Guidelines — T-Cell LymphomasESMO Clinical Practice Guidelines — Peripheral T-Cell LymphomasWHO Classification of Haematopoietic and Lymphoid TissuesContent on this website is for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. It is not a substitute for evaluation by a qualified healthcare professional. Always seek the advice of your physician or other qualified provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. In case of a medical emergency, contact emergency services immediately. No doctor–patient relationship is established by use of this site or by contacting the clinic through the site.