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Clonal marrow overproduction with thrombosis and transformation risk
Myeloproliferative neoplasms include polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. They share JAK2, CALR or MPL mutations and a risk of thrombosis, bleeding and progression to myelofibrosis or acute leukemia. Treatment focuses on symptom control, thrombotic risk reduction and surveillance for transformation.
Haematology & Haemato-Oncology
Authored and reviewed by Dr. Sachita Baniya (MBBS, FCPS (Clinical Haematology), NMC 20158). Evidence-based, no fabricated outcomes.
Myeloproliferative neoplasms include polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. They share JAK2, CALR or MPL mutations and a risk of thrombosis, bleeding and progression to myelofibrosis or acute leukemia. Treatment focuses on symptom control, thrombotic risk reduction and surveillance for transformation.
Reviewed by Dr. Sachita Baniya, MBBS, FCPS — Consultant Haemato-Oncologist & Clinical Hematologist (NMC 20158). For evaluation, contact the respective hospital or cancer centre — Kathmandu Cancer Center (KCC) Nepal, Civil Service Hospital Kathmandu, or Advanced Care Hospital.
Diagnosis requires blood count abnormalities, marrow morphology and mutation testing. JAK2 V617F, JAK2 exon 12, CALR and MPL mutations support the diagnosis; triple-negative cases need careful exclusion of other causes. Baseline spleen size, symptom burden and thrombosis history guide risk assessment.
Polycythaemia vera aims to control haematocrit and reduce thrombosis risk with phlebotomy, aspirin and cytoreduction where indicated. Essential thrombocythaemia management depends on platelet count and thrombosis risk. Myelofibrosis treatment addresses symptoms, anaemia and splenomegaly with JAK inhibitors, supportive care and transplant in selected high-risk patients.
Guidelines referenced:
WHO Classification of Haematopoietic and Lymphoid TumoursNCCN Guidelines — Myeloproliferative NeoplasmsEuropean LeukemiaNet MPN consensusContent on this website is for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. It is not a substitute for evaluation by a qualified healthcare professional. Always seek the advice of your physician or other qualified provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. In case of a medical emergency, contact emergency services immediately. No doctor–patient relationship is established by use of this site or by contacting the clinic through the site.