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High cure rates demand equal attention to what happens after treatment
Hodgkin lymphoma is a lymphoid malignancy characterised by Reed-Sternberg cells in an inflammatory background. It often presents with painless lymphadenopathy, sometimes with B symptoms. Staging with PET-CT and response-adapted treatment achieve high cure rates, but survivors need long-term surveillance for cardiac, pulmonary, thyroid and second-cancer risks.
Haematology & Haemato-Oncology
Authored and reviewed by Dr. Sachita Baniya (MBBS, FCPS (Clinical Haematology), NMC 20158). Evidence-based, no fabricated outcomes.
Hodgkin lymphoma is a lymphoid malignancy characterised by Reed-Sternberg cells in an inflammatory background. It often presents with painless lymphadenopathy, sometimes with B symptoms. Staging with PET-CT and response-adapted treatment achieve high cure rates, but survivors need long-term surveillance for cardiac, pulmonary, thyroid and second-cancer risks.
Reviewed by Dr. Sachita Baniya, MBBS, FCPS — Consultant Haemato-Oncologist & Clinical Hematologist (NMC 20158). For evaluation, contact the respective hospital or cancer centre — Kathmandu Cancer Center (KCC) Nepal, Civil Service Hospital Kathmandu, or Advanced Care Hospital.
An excisional lymph node biopsy is preferred for diagnosis. Immunohistochemistry confirms the classic phenotype, and staging uses PET-CT plus clinical assessment. Bone marrow biopsy is reserved for selected cases. Baseline fertility, cardiac and pulmonary assessment is part of planning because treatment exposures matter for decades.
Early-stage disease is usually treated with combined-modality therapy or chemotherapy alone, guided by risk and interim response. Advanced disease is treated with multi-agent chemotherapy, with radiotherapy reserved for residual or bulky sites. Relapsed disease may be treated with salvage chemotherapy followed by autologous transplant, and selected patients benefit from novel agents or CAR-T. Survivorship care addresses cardiovascular risk, lung health, thyroid function, fertility and second malignancies.
Guidelines referenced:
NCCN Guidelines — Hodgkin LymphomaESMO Clinical Practice Guidelines — Hodgkin LymphomaLugano classification for lymphoma stagingContent on this website is for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. It is not a substitute for evaluation by a qualified healthcare professional. Always seek the advice of your physician or other qualified provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. In case of a medical emergency, contact emergency services immediately. No doctor–patient relationship is established by use of this site or by contacting the clinic through the site.