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Expanding transplant access with family donors and modern GVHD prophylaxis
Haplo-identical transplant uses stem cells from a half-matched donor, usually a parent, child or sibling. Modern conditioning and post-transplant cyclophosphamide-based GVHD prophylaxis have made this approach widely available. It is an important option for patients without a fully matched donor, but infection and GVHD risks remain significant.
Haematology & Haemato-Oncology
Authored and reviewed by Dr. Sachita Baniya (MBBS, FCPS (Clinical Haematology), NMC 20158). Evidence-based, no fabricated outcomes.
Haplo-identical transplant uses stem cells from a half-matched donor, usually a parent, child or sibling. Modern conditioning and post-transplant cyclophosphamide-based GVHD prophylaxis have made this approach widely available. It is an important option for patients without a fully matched donor, but infection and GVHD risks remain significant.
Reviewed by Dr. Sachita Baniya, MBBS, FCPS — Consultant Haemato-Oncologist & Clinical Hematologist (NMC 20158). For evaluation, contact the respective hospital or cancer centre — Kathmandu Cancer Center (KCC) Nepal, Civil Service Hospital Kathmandu, or Advanced Care Hospital.
It is used when a fully matched sibling or unrelated donor is unavailable or when urgency does not allow a prolonged search. Donor selection considers HLA matching, donor age, health, ABO compatibility and viral status. The choice between haplo-identical, matched unrelated and cord blood transplant is individualised.
The graft is usually peripheral blood stem cells or bone marrow. Post-transplant cyclophosphamide is commonly used to prevent GVHD, alongside other immunosuppression. Engraftment, infection and GVHD are monitored closely. Outcomes have improved substantially, but chronic GVHD and infection remain important causes of morbidity.
Guidelines referenced:
EBMT/ESH handbook on haematopoietic stem cell transplantationAmerican Society for Transplantation and Cellular Therapy guidanceNCCN Guidelines — Acute LeukemiasContent on this website is for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. It is not a substitute for evaluation by a qualified healthcare professional. Always seek the advice of your physician or other qualified provider with any questions regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. In case of a medical emergency, contact emergency services immediately. No doctor–patient relationship is established by use of this site or by contacting the clinic through the site.