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Motor neuron disease (ALS) causes progressive muscle weakness and atrophy — early signs include hand weakness, foot drop and slurred speech.
Quick Answer
Motor neuron disease (ALS) causes progressive muscle weakness and atrophy — early signs include hand weakness, foot drop and slurred speech. Dr. Jitendra Prasad Yadav (NMC 8029, 15+ years of clinical experience) evaluates motor neuron disease at Kathmandu Neurology Clinic & Cognitive Center, 117 Lal Durbar Marg, Kathmandu, Bagmati Province 44600, Nepal — evidence-based, medically reviewed.
Motor neuron disease (MND), including amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disorder affecting motor neurons — causing muscle weakness, atrophy and eventually paralysis while sparing sensation and cognition (in most cases). Early recognition enables treatment, clinical trial access and advance care planning.
Excessive emotional lability
Unknown in ~90% (sporadic)
Management is individualized and discussed with benefits, limitations, and follow-up.
Genetic mutations (SOD1, C9orf72 — ~10% familial)
Neurology
Motor Neuron Disease: Early Signs and When to Seek Evaluation
Motor neuron disease (ALS) causes progressive muscle weakness — often starting in the hands or feet. Learn the early signs and why early diagnosis matters.
Health
ALS: Amyotrophic Lateral Sclerosis Warning Signs
ALS causes progressive muscle weakness — affecting voluntary movement. Early recognition enables earlier treatment and planning.
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Reviewed by Dr. Jitendra Prasad Yadav • Last reviewed: 2026-11-10
Content is educational and aligns with standard medical references; individual evaluation may vary. External links provide context and do not imply endorsement.
Doctor — medically reviewed
Dr. Jitendra Prasad Yadav
Consultant Neurologist & Headache Specialist • MBBS, MD (Internal Medicine), FICN (Neurology), FCNV, FIHM • NMC 8029
This condition guide was medically reviewed by Dr. Jitendra Prasad Yadav.
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Emergency
For sudden neurologic change, thunderclap headache, or seizure >5 min, seek emergency services now.