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Mantle cell lymphoma is an aggressive B-cell lymphoma associated with cyclin D1 overexpression and t(11;14).
Quick Answer
Mantle cell lymphoma is an aggressive B-cell lymphoma associated with cyclin D1 overexpression and t(11;14). Dr. Sachita Baniya (NMC 20158, 8+ years of clinical experience in haematology and haemato-oncology) evaluates mantle cell lymphoma at Kathmandu Neurology Clinic & Cognitive Center, 117 Lal Durbar Marg, Kathmandu, Bagmati Province 44600, Nepal — evidence-based, medically reviewed.
Mantle cell lymphoma often presents with lymphadenopathy, splenomegaly and bone marrow involvement. It behaves more aggressively than follicular lymphoma and usually requires treatment. Modern targeted therapy and transplant have improved disease control.
Biopsy with immunohistochemistry confirms cyclin D1 expression, and FISH detects t(11;14). PET-CT and bone marrow assessment stage the disease, while MIPI and Ki-67 inform risk.
Younger fit patients may receive intensive chemoimmunotherapy followed by autologous transplant and maintenance. Older or less fit patients may receive BTK inhibitor-based therapy. Relapsed disease may be treated with targeted agents, CAR-T or allogeneic transplant.
Management is individualized and discussed with benefits, limitations, and follow-up.
There is no proven prevention. Early evaluation of persistent lymphadenopathy is the main practical step.
Red flags — seek urgent care
It is often treatable but not usually curable with standard therapy. Intensive first-line treatment and transplant can produce long remissions in selected patients.
The MIPI score combines age, performance status, LDH and white cell count to estimate prognosis and guide treatment intensity.
BTK inhibitors are effective in mantle cell lymphoma, particularly in older or less fit patients and in relapsed disease. They are continued until progression in many regimens.
No. Autologous transplant is considered for selected fit patients in first remission. Allogeneic transplant may be considered in selected high-risk or relapsed cases.
Blastoid variant is a more aggressive form with a higher proliferation rate and worse prognosis. It requires intensive treatment planning.
Yes, it can involve the gastrointestinal tract, sometimes as multiple polyps. Endoscopy may be considered when symptoms suggest involvement.
PET-CT and clinical assessment are used. Bone marrow and molecular testing may be repeated in selected cases.
Regular clinical review, blood counts and imaging when indicated. Survivorship care addresses infection risk and late effects.
Diagnosis, staging and treatment planning for Hodgkin and non-Hodgkin lymphomas.
High-dose therapy with the patient's own stem cells for myeloma and selected lymphomas.
Eligibility assessment, referral coordination and follow-up for CAR-T cell therapy.
Diffuse large B-cell lymphoma is the most common aggressive lymphoma, typically presenting as a rapidly growing mass.
Follicular lymphoma is a common indolent B-cell lymphoma that often grows slowly and may be monitored for years.
Burkitt lymphoma is a highly aggressive B-cell lymphoma with a very high proliferation rate that needs urgent treatment.
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Reviewed by Dr. Jitendra Prasad Yadav • Last reviewed: 2026-11-10
Content is educational and aligns with standard medical references; individual evaluation may vary. External links provide context and do not imply endorsement.
Doctor — medically reviewed
Dr. Sachita Baniya
Consultant Haemato-Oncologist & Clinical Hematologist • MBBS, FCPS (Clinical Haematology) • NMC 20158
This condition guide was medically reviewed by Dr. Sachita Baniya.
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