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Locked-in syndrome causes complete paralysis of voluntary muscles except eye movements — consciousness is preserved but communication is severely limited.
Quick Answer
Locked-in syndrome causes complete paralysis of voluntary muscles except eye movements — consciousness is preserved but communication is severely limited. Dr. Jitendra Prasad Yadav (NMC 8029, 15+ years of clinical experience) evaluates locked-in syndrome at Kathmandu Neurology Clinic & Cognitive Center, 117 Lal Durbar Marg, Kathmandu, Bagmati Province 44600, Nepal — evidence-based, medically reviewed.
Locked-in syndrome (LIS) is a rare neurological condition causing complete paralysis of all voluntary muscles except vertical eye movements and blinking — consciousness and cognitive function are fully preserved. Most commonly caused by a pontine stroke affecting the ventral pons. Communication is possible only through eye movements or blinking.
Blinking preserved
No speech
Management is individualized and discussed with benefits, limitations, and follow-up.
No limb movement
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Reviewed by Dr. Jitendra Prasad Yadav • Last reviewed: 2026-11-10
Content is educational and aligns with standard medical references; individual evaluation may vary. External links provide context and do not imply endorsement.
Doctor — medically reviewed
Dr. Jitendra Prasad Yadav
Consultant Neurologist & Headache Specialist • MBBS, MD (Internal Medicine), FICN (Neurology), FCNV, FIHM • NMC 8029
This condition guide was medically reviewed by Dr. Jitendra Prasad Yadav.
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For sudden neurologic change, thunderclap headache, or seizure >5 min, seek emergency services now.